In this paper I argue that warrant for Lewis’ principle of recombination presupposes warrant for a combinatorial analysis of intrinsicality, which in turn presupposes warrant for the principle of recombination. This, I claim, leads to a vicious circularity: warrant for neither doctrine can get off the ground.

The Scottish Mental Health Arts and Film Festival has seen hundreds of arts, public and community groups coproduce over 300 events to over 25,000 audience members. Integral to this arts-based approach, in contrast to social marketing or public education models, is the notion that mental health is an essentially contested concept whereby meanings are negotiated and debate encouraged. With emerging evidence that the festival is an ef ective way of engaging people intellectually and emotionally, we explore ethical issues, challenges and (...) paradoxes that have emerged as the festival has developed. Consideration is given to issues of power, purpose, opportunity costs, reach, impact, programming risks, and participation from those with experience of mental ill-health. Throughout, we explore practical implications for funding, managing, programming, marketing and evaluation of this and similar endeavours. (shrink)

De Bie et al. provide a novel framework for assessing ethical considerations in artificial womb technology (AWT) based on four phases of human prenatal development (DeBie 2023). As the authors note...

Uterus transplantation is an emerging technology adding to the arsenal of treatments for infertility; specifically the only available treatment for uterine factor infertility. Ethical investigations concerning risks to uteri donors and transplant recipients have been discussed in the literature. However, missing from the discourse is the potential of uterus transplantation in other groups of genetically XY women who experience uterine factor infertility. There have been philosophical inquiries concerning uterus transplantation in genetically XY women, which includes transgender women and women with (...) complete androgen insufficiency syndrome. We discuss the potential medical steps necessary and associated risks for uterus transplantation in genetically XY women. Presently, the medical technology does not exist to make uterus transplantation a safe and effective option for genetically XY women, however this group should not be summarily excluded from participation in trials. Laboratory research is needed to better understand and reduce medical risk and widen the field to all women who face uterine factor infertility. (shrink)

Harms and risks to groups and third-parties can be significant in the context of research, particularly in data-centric studies involving genomic, artificial intelligence, and/or machine learning technologies. This article explores whether and how United States federal regulations should be adapted to better align with current ethical thinking and protect group interests. Three aspects of the Common Rule deserve attention and reconsideration with respect to group interests: institutional review board (IRB) assessment of the risks/benefits of research; disclosure requirements in the informed (...) consent process; and criteria for waivers of informed consent. In accordance with respect for persons and communities, investigators and IRBs should systematically consider potential group harm when designing and reviewing protocols, respectively. Research participants should be informed about any potential group harm in the consent process. We call for additional public discussion, empirical research, and normative analysis on these issues to determine the right regulatory and policy path forward. (shrink)

As the technology for ectogenesis continues to advance, the ethical implications of such developments should be thoroughly and proactively explored. The possibility of full ectogenesis remains hypothetical at present, and myriad concerns regarding the safety and efficacy of the technology must be evaluated and addressed, while pressing moral considerations should be fully deliberated. However, it is conceivable that the technology may become sufficiently well established in the future and that eventually full ectogenesis might be deemed ethically acceptable as a reproductive (...) alternative to gestation within a human womb under certain circumstances. If the safety and efficacy of full ectogenesis are established, if ethical dilemmas are sufficiently well addressed, and if the technology is offered as a reproductive option to cisgender heterosexual individuals or couples desiring to become parents, there is a moral obligation grounded in social justice to ensure that full ectogenesis be made available to individuals or couples identifying as members of sexual‐ or gender‐minority groups who likewise seek to pursue parenthood. We examine the history of access to current family‐building options, including assisted reproductive technology, surrogacy and adoption, for these populations and conclude that in the absence of robust empirical evidence suggesting an increased risk of harm to children of individuals and couples who identify as members of sexual‐ or gender‐minority groups, equitable access to ectogenesis as a pathway to parenthood for sexual and gender minorities must be assured as a matter of reproductive justice. (shrink)

Suppose that a person P 1 dies some time during 1978. Many years later, the resurrection world, a perennial object of Christian concern, begins on the morning of the day of judgment. On its first morning there are in that world distinct persons, P 2 and P 3 , each of whom is related in remarkably intimate ways to P 1 . You are to imagine that each of them satisfies each of the criteria or conditions necessary for identity with (...) P 1 to some extent, that both of them satisfy these conditions to exactly the same extent, and that every other denizen of the resurrection world satisfies each of these conditions to a lesser extent than P 2 and P 3 do. Thus, for example, philosophers often claim that bodily continuity is a necessary condition for personal identity. If it is, you might assume that the body P 2 has on the morning of the day of judgment contains some of the same atoms the body of P1 1 contained when P 1 died, and that P 2 's body on that day contains exactly n atoms from P 1 's body at the time of death just in case P 3 's body on that day contains exactly n atoms from P 1 's body at the time of death. Or, again, some philosophers hold that connectedness of memory is necessary for personal identity. If so, you are to suppose that on the morning of the day of judgment P 3 seems to remember some of the events in the life of P 1 having happened to him, and that P 3 seems to remember a certain event in the life of P 1 having happened to him just in case P 2 seems to remember that very event in the life of P 1 having happened to him. You are to fill in the details by adding complete parity between P 2 and P 3 with respect to similarity of DNA molecules, character traits and whatever else you deem relevant to personal identity. And, finally, you are to complete the story by imagining that P 2 and P 3 live very different sorts of lives in the resurrection world. To heighten the poignancy of the story, you might imagine that P 2 enjoys forever after the beatitude promised to the blessed while P 3 suffers the everlasting torments reserved for the damned. (shrink)

© 2017. The American Astronomical Society. All rights reserved.We present new observations of the low-mass companion to HD 984 taken with the Gemini Planet Imager as a part of the GPI Exoplanet Survey campaign. Images of HD 984 B were obtained in the J and H bands. Combined with archival epochs from 2012 and 2014, we fit the first orbit to the companion to find an 18 au orbit with a 68% confidence interval between 14 and 28 au, an eccentricity (...) of 0.18 with a 68% confidence interval between 0.05 and 0.47, and an inclination of 119°with a 68% confidence interval between 114°and 125°. To address the considerable spectral covariance in both spectra, we present a method of splitting the spectra into low and high frequencies to analyze the spectral structure at different spatial frequencies with the proper spectral noise correlation. Using the split spectra, we compare them to known spectral types using field brown dwarf and low-mass star spectra and find a best-fit match of a field gravity M6.5 ±1.5 spectral type with a corresponding temperature of K. Photometry of the companion yields a luminosity of log=2.88 ± 0.07 dex with DUSTY models. Mass estimates, again from DUSTY models, find an age-dependent mass of 34 ±1 to 95 ±4 M Jup. These results are consistent with previous measurements of the object. (shrink)

This unique volume collects some of the best recent work on the philosophical challenge that religious diversity poses for religious belief. Featuring contributors from philosophy, religious studies, and theology, it is unified by the way in which many of the authors engage in sustained critical examination of one another's positions. John Hick's pluralism provides one focal point of the collection. Hick argues that all the major religious traditions make contact with the same ultimate reality, each encountering it through a variety (...) of culturally shaped forms of thought and experience but all offering equally effective paths to salvation or liberation. Another central position is William P. Alston's defense of the Christian practice of forming beliefs about manifestations of God in response to experiences of divine presence or activity. Articles by Hick and Alston develop their arguments and other selections respond, criticizing or defending various aspects of one or both positions. Religious skepticism, religious exclusivism, religious inclusivism, and other perspectives are also represented. In the introduction, the editors suggest connections among the articles and report on additional exchanges between the contributors. The only anthology that provides comprehensive coverage of the current philosophical debate about religious diversity, The Philosophical Challenge of Religious Diversity is ideal for courses and seminars on the philosophy of religion, philosophical theology, and world religions. (shrink)

The world religions make conflicting claims about the nature of ultimate reality, and they all appeal to experience for justification of their claims. The experiential justifications for conflicting religious beliefs thus seem to be mutually destructive. One response to this situation, advocated by John Hick, is to reinterpret traditional religious claims in ways that eliminate the conflicts; another, favored by William P. Alston, is to defend the rationality of continuing, despite the conflicts, to engage in the doxastic practice of one’s (...) own religion. I begin this paper with a summary of the criticism of Alston’s defense that I have spelled out in greater detail elsewhere. After arguing that Alston’s conclusions require significant modification, I go on to defend the modified Alstonian conclusions against objections recently raised by Hick. I conclude by suggesting a view that seems to me to combine the best features of Alston’s and Hick’s approaches to religious pluralism. (shrink)

This volume is an entry in the Point/counterpoint Series edited by James P. Sterba and Rosemarie Tong. In it Robert Audi and Nicholas Wolterstorff debate the place of religious convictions in politics. First, each of them presents an initial statement of his own views. Next, each of them responds critically to the views of the other. And, finally, Audi provides a brief summary of the chief points of agreement and disagreement. The two initial statements are expanded versions of papers Audi (...) and Wolterstorff presented at a conference on religion and liberalism at the University of Notre Dame. Those papers are included in a recently published volume of conference proceedings. (shrink)

BackgroundThe ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines are widely endorsed but compliance is limited. We sought to determine whether journal-requested completion of an ARRIVE checklist improves full compliance with the guidelines.MethodsIn a randomised controlled trial, manuscripts reporting in vivo animal research submitted to PLOS ONE (March–June 2015) were randomly allocated to either requested completion of an ARRIVE checklist or current standard practice. Authors, academic editors, and peer reviewers were blinded to group allocation. Trained reviewers performed outcome adjudication (...) in duplicate by assessing manuscripts against an operationalised version of the ARRIVE guidelines that consists 108 items. Our primary outcome was the between-group differences in the proportion of manuscripts meeting all ARRIVE guideline checklist subitems.ResultsWe randomised 1689 manuscripts (control: n = 844, intervention: n = 845), of which 1269 were sent for peer review and 762 (control: n = 340; intervention: n = 332) accepted for publication. No manuscript in either group achieved full compliance with the ARRIVE checklist. Details of animal husbandry (ARRIVE subitem 9b) was the only subitem to show improvements in reporting, with the proportion of compliant manuscripts rising from 52.1 to 74.1% (X2 = 34.0, df = 1, p = 2.1 × 10−7) in the control and intervention groups, respectively.ConclusionsThese results suggest that altering the editorial process to include requests for a completed ARRIVE checklist is not enough to improve compliance with the ARRIVE guidelines. Other approaches, such as more stringent editorial policies or a targeted approach on key quality items, may promote improvements in reporting. (shrink)

This volume brings together fourteen of the best papers by the late Philip Quinn, one of the world's leading philosophers of religion. It covers the following topics: religious epistemology, religious ethics, religion and tragic dilemmas, religion and political liberalism, topics in Christian philosophy, and religious diversity.

The relationship between humanity and the soil is an increasingly important topic in social theory. However, conceptualisations of the soil developed by anticolonial thinkers at the high point of the movement for self-determination between the 1940s and the 1970s have remained largely ignored. This is a shame, not least because theorists like Eric Williams, Walter Rodney, Suzanne Césaire and Amílcar Cabral were concerned with the soil. Building on recent work on human-soil relations and decolonial ecology, we argue that these four (...) thinkers conceptualised the connection between soil, empire, and anticolonial revolt. Williams and Rodney ground understanding of soil degradation in global relations of economic power, while Césaire and Cabral reconceptualise postcolonial nationhood in terms of the mutability and diversity of the soil. The article concludes by suggesting that these two anticolonial counterpoints, global connectivity and more-than-human identification, anticipate and deepen contemporary attempts to decolonise ecological thinking. (shrink)

We recall some of the early occurrences of the notions of interactivity and symmetry in the operational and denotational semantics of programming languages. We suggest some connections with ludics.

We look at a hierarchical arrangement of ideals in an MV -algebra. The principal classes of ideals studied are the maximals, the primes, the local and perfect ideals and the semi-locals. Beyond these special classes of ideals are the general ideals. Herein we study some relationships among these classes and, more specifically, the products of ideals of these classes. Among the results obtained are the square of a prime ideal is a local ideal, the finite product of prime ideals is (...) a semilocal ideal. We also show that the set of local ideals shares many of the properties of the class of prime ideals, as the Lying Over Theorem and the Going Up Theorem. (shrink)

This book examines the relationship between law and scientific advancement, with a particular focus on the theory of evolution and medical innovation. Historically, the law has struggled to keep pace with modern medical advances. The authors demonstrate that the laws that govern human behaviour must evolve in response to such advances."--Provided by publisher.